![]() Both Cav-VP7 R 0 and SG33-VP7 stimulated an antigen-specific CD4 + response and Cav-VP7 R 0 stimulated substantial proliferation of antigen-specific CD8 + lymphocytes. Humoral responses were elicited against VP7 in almost all animals that received the recombinant vectors. ![]() ![]() In this paper we have evaluated the capacity of the BTV-2 serotype VP7 core protein expressed by either a non-replicative canine adenovirus type 2 (Cav-VP7 R 0) or a leporipoxvirus (SG33-VP7), to induce immune responses in sheep. Viral-based vectors as antigen delivery systems display considerable promise as veterinary vaccine candidates. The major group-reactive antigen of BTV, VP7, is conserved in the 26 serotypes described so far, and its role in the induction of protective immunity has been proposed. The need for new vaccines has been highlighted by the occurrence of repeated outbreaks caused by different BTV serotypes since 1998. Abstractīluetongue virus (BTV) is an economically important Orbivirus transmitted by biting midges to domestic and wild ruminants. This article has been cited by other articles in PMC.
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